Rheumatoid arthritis (RA) is a chronic inflammatory disorder that affects the joints, leading to pain, swelling, and stiffness. One of the most common symptoms experienced by RA patients is fatigue, which can significantly impact their quality of life. A recent study published in the journal Rheumatology sheds light on the factors that contribute to fatigue in RA patients.
The study, conducted by Anna M.P. Boeren and colleagues from the Leiden University Medical Center in the Netherlands, focused on RA patients with mono- or oligo-arthritis and high Patient Global Assessment (PGA) at diagnosis. The researchers analyzed data from two early RA cohorts, including a total of 1,560 patients, to examine the course of fatigue over a five-year period.
The results of the study revealed that patients with higher tender joint count and higher PGA at diagnosis experienced a more severe course of fatigue. Additionally, those who presented with mono- or oligo-arthritis at diagnosis remained more fatigued compared to those with polyarthritis. Interestingly, an inverse association was found for the swollen joint count.
Furthermore, the study highlighted a subgroup of patients who presented with mono- or oligo-arthritis and PGA ≥50 mm, who were identified as the most fatigued over time. These patients had a significantly higher level of fatigue compared to those with polyarthritis and lower PGA scores. The researchers emphasized the importance of exploring nonpharmacological treatments, such as cognitive behavioral therapy, for this subgroup of RA patients, as they have the highest unmet need.
Overall, this study provides valuable insights into the factors that contribute to fatigue in RA patients, emphasizing the importance of personalized treatment approaches based on individual characteristics. Further research is needed to better understand the management of fatigue in RA patients and improve their quality of life.
In conclusion, it is essential for healthcare providers to consider the impact of fatigue on RA patients and tailor treatment strategies accordingly. By addressing the specific needs of patients with mono- or oligo-arthritis and high PGA at diagnosis, it is possible to improve their overall well-being and alleviate the burden of fatigue in this population.
